Describe the alteration to drug response due to hepatic disease.
Metabolic clearance is usually constant and independent of dose. TRUE/FALSE
For drugs with an extraction ratio of nearly 0, a change in liver blood flow produces a nearly proportional change in clearance. TRUE/FALSE
Alfentanil is an example of a drug whose hepatic metabolism is capacity-limited. TRUE/FALSE
In cirrhosis, hepatic drug clearance is usually reduced. TRUE/FALSE
CYP3A4 is responsible for nearly half of all drug metabolism. TRUE/FALSE. Hint…this is the enzyme system affected by grapefruit juice (and interestingly, propofol).