BT_PO 1.82a Outline basic cellular physiology in particular The structure of the cell membrane and trans- membrane transport mechanisms The composition and regulation of intracellular fluid The generation of the trans-membrane potential Energy production by metabolic processes in cells

AKA read most of Ganong Chapters 1 and 2

The intracellular compartment contains about 5% of body water     T/F

Colligative properties are dependent upon the types of particles in a solution    T/F

The sodium/potassium pump prevents cellular oedema AND contributes to the membrane potential     T/F

Oxidative phosphorylation occurs in red blood cells     T/F

In some cells glucose crosses the cell membrane by secondary active transport     T/F

Bonus question (the answer can be worked out from material in chapter one) – the pH electrode has a semi-permeable membrane with the selective diffusion of hydrogen ions creating an electrical gradient which is measured. What equation is used to calculate the concentration of hydrogen ions from the electrical gradient?

And remember it’s the webinar today!

BT_RT 1.4 Discuss oxygen delivery and outline indicators of tissue oxygenation in resuscitation

Amazing sunrise this morning!

I though that this topic fit comfortably with yesterday’s post on the consequences of anaemia.

Oxygen delivery is an important issue for us. Knowing what happens as tissue oxygenation becomes impaired, will help you to understand the basis of the indicators we use.

Nunn’s Respiratory Physiology has a comprehensive chapter on Oxygen, Oh’s Manual of Intensive Care chapter on Oxygen Therapy (Ch 28) contains good information on measures of tissue oxygenation at the start of the chapter and here is an article from BJA Education (I think the CPT section is beyond the scope of the primary exam )

BT_RT 1.4 Describe oxygen delivery and outline the use of indicators of tissue oxygenation (base deficit, lactate, mixed venous oxygen saturation) in resuscitation

All the statements below are fairly core

In health, at rest, less than 30% of oxygen delivered to the tissues is used T/F

All organs have the capacity to increase their oxygen extraction ratio if oxygen supply is decreased T/F

Mixed venous blood can be sampled from a central line T/F

Lactate is only produced under anaerobic conditions  T/F

Base excess is positive with lactic acidosis T/F



BT_GS 1.2 Explain receptor activity with regard to: Ionic fluxes, Second messengers and G proteins, Nucleic acid synthesis, Evidence for the presence of receptors, Regulation of receptor number and activity

Signal transduction refers to the process by which receptors act to mediate their physiologic action  T/F

Important second messengers include cAMP, cGMP , Ca2+ and ITP        T/F

GPCRs have seven membrane-spanning alpha helices       T/F

Some receptors are intracellular             T/F

Receptors can be down-regulated by endocytosis and degradation by lysosymes     T/F