When I think about blood clotting, I tend to think of the pathways which aid coagulation, rather than those which prevent thrombosis. Clearly in healthy individuals the pro and anti thrombotic systems are in a delicate, finely tuned balance.
I used Guyton and Hall Textbook of Medical Physiology as the reference text for today’s post
BT_PO 1.113 Describe the physiological mechanisms of limiting and preventing thrombosis
Smooth endothelium prevents exposure to collagen which stops the activation of the extrinsic coagulation pathway T/F
Thrombomodulin binds thrombin, increasing the risk of thrombosis T/F
Heparin is released endogenously from basophils T/F
The muscle pump in the lower limbs plays a role in preventing thrombosisT/F
Endogenous anticoagulants include antithrombin III, protein C and protein S T/F
Endogenous activation of the coagulation cascade causes a concurrent activation of a thrombolytic process T/F
One of my children is studying year 12 biology this year – it is WAY more high tech than when I studied the subject 30 yrs ago. They have been studying genetics and she told me recently that transgenic goats have been created whom produce large quantities of human antithrombin III in their milk which is extracted for therapeutic use – wow! Not really relevant to today’s post, but there are also transgenic sheep who express α1-antitrypsin in their milk.