Clearly a favourite of mine (see yesterday’s post and also this one)

BT_GS 1.3 Define and explain dose-effect relationships of drugs with reference to:

· Graded and quantal response

· Therapeutic index

· Potency and efficacy

· Competitive and non-competitive antagonists

· Partial agonists, mixed agonist-antagonists and inverse agonists

· Additive and synergistic effects of drug combinations

BT_GS 1.4 Describe efficacy and potency with reference to dose- response curves

Use the curve below as a basis for your graphs

1.Add axes to indicate that the curve is a graded dose-response curve for a full agonist. Show the ED50.

2.Draw on the same axes, the same agonist in the presence of a competitive antagonist. Indicate the important features on your curve.

3.Show a partial agonist (E=0.8) which is equipotent to the full agonist drawn

4.Show on the graph with the full agonist, a more potent partial agonist capable of producing 50% maximal effect

5.Are any of the curves 2-4 compatible with a graph representing the full agonist in the presence of a non competitive (irreversible) antagonist? If so, which one?

I’ll post the answers later in the week