BT_PO 1.54 Pharmacology of beta receptor blocking agents

jan 2006 156

I asked about these drugs in the recent in exams and was fascinated (read horrified and astounded) that only one person had a plausible explanation as to how these little chaps cause hypotension…..

These drugs are actually mentioned in 5 LOs BT_PO 1.54 and BT_PO 1.57-1.60

We see a lot of patients on these drugs, partly because they have been shown to confer a survival advantage in people with heart failure, so it is probably a good idea to know a bit about them…

BT_PO 1.54 Describe the pharmacology of commonly used alpha and beta receptor blocking agents, their clinical use, adverse effects and use in the perioperative period

 

Metoprolol is metabolised by the CPY2D6, and hence prone to large inter individual variation in response   TRUE/FALSE

Beta1 selective blockers produce a significant reduction in blood pressure when given to normotensive individuals     TRUE/FALSE

Hypotension with beta blockers is mediated by the dilation of vessels in skeletal smooth muscle   TRUE/FALSE

Beta blockers cause a reduction in the release of renin TRUE/FALSE

Some beta blockers have an alpha agonist effect TRUE/FALSE