Outline the principles of antibiotic prophylaxis for surgical site infections using cefazolin in knee joint replacement surgery as an example.
BT_PO 1.131 Explain the principles of antibiotic prophylaxis.
Thanks to guest blogger Nic for contributing the following T/F statements.
T/F cefazolin is a third generation cephalosporin
T/F cefazolin is a broad spectrum antibiotic with good gram positive and gram negative cover *
T/F cefazolin is bacteriocidal
T/F beta lactam antibiotics disrupt bacterial cell wall synthesis
T/F prophylactic antibiotics are best given immediately prior to skin incision
T/F cefazolin should be administered in a dose of 15 mg/kg, up to 2 g
T/F cefazolin should not be used in a patient with penicillin allergy **
T/F during long operations, cefazolin should be re-dosed every 4 hours
T/F cefazolin should be re-dosed after blood loss > 1000 mL
*what is the main skin organism we are using cefazolin to cover?
** what is the incidence of allergic cross reactivity between penicillin and cefazolin, and why does it occur? (see reference 2)
1. any of the pharmacology books (Stoelting, Evers & Maze etc) have a chapter on antibiotics
2. Vorobeichik, etal. Misconceptions surrounding penicillin allergy: implications for anesthesiologists. Anesthesia & Analgesia, 2018; 127: 642-649.
What surgical antibiotic prophylaxis guidelines do you use in your hospital?