Antibiotics

BT_PO 1.3 Describe the adverse effects of antimicrobial agents Discuss the role of antibiotic prophylaxis in preventing infection and the identification of patients requiring it.

I remember listening to a radio program a few years ago about the development of streptomycin. During WWII Sulfanilamide and (later) Penicillin were available, but there was no treatment for gram negative infections, which were obviously common after gunshot wounds to the abdomen. Selman Waksman was looking for such a drug amongst soil microbes, and found Streptomycin in 1943.

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Here is a picture of someone making Streptomycin at a Merck Plant.

We don’t use streptomycin much now, but it sobering to think that it wasn’t that long ago that we couldn’t treat these infections at all.

 

 

 

 

 

 

T/F Antimicrobial effect of gentamicin is related to the area under the concentration time curve

T/F Clindamicin is effective against anaerobes

T/F Aminoglycoside ototoxicity is a dose dependent phenomenon

T/F If a patient has an anaphylactic reaction to penicillin there is a 15% chance they will also react to cefazolin

T/F Cefazolin is effective against most oral anaerobes