I rarely use this drug as I worry about the ethical implications of amnesia in a patient who believes they were unconscious. In an anxious patient I prefer to make the experience as pleasant as possible with such activities as talking, hand holding, my ‘Lullabies for Grown-ups’ playlist and making the theatre table up as a cosy bed with the forced air warmer already running. Even so, some people are so anxious that midazolam is totally appropriate as an anxiolytic, and it has a role in my practice when performing procedures.
The time to peak effect of midazolam is 2 minutes TRUE/FALSE
Midazolam is water soluble in an acidic solution TRUE/FALSE
Midazolam can be given orally TRUE/FALSE
Midazolam can be used as an anticonvulsant TRUE/FALSE
Upper airway reflexes are preserved with midazolam TRUE/FALSE
This question covers some fundamental material which is built upon in other physiology, pharmacology and anatomy topics.
A de-innervated transplanted heart has an intrinsic rate of 20 bpm TRUE/FALSE
Sympathetic innervation is responsible for sinus arrhythmia TRUE/FALSE
A right sided sympathetic block will cause negative chronotropy TRUE/FALSE
A right sided vagal block will cause negative chronotropy TRUE/FALSE
At rest, parasympathetic tone predominates TRUE/FALSE
And it will come as a surprise to no-one reading the posts this week to find I’ve been reading Ganong again.
Vitamin D is hydroxylated to calcitriol in the proximal tubules of the kidney T/F
Calcitriol increases calcium reabsorption in the proximal tubules of the kidney T/F
The O2 sensor to control erythropoietin production is probably a heme protein T/F
Increasing catecholamines will stimulate erythropoietin production T/F
Erythropoietin is also produced in the brain T/F
AKA read most of Ganong Chapters 1 and 2
The intracellular compartment contains about 5% of body water T/F
Colligative properties are dependent upon the types of particles in a solution T/F
The sodium/potassium pump prevents cellular oedema AND contributes to the membrane potential T/F
Oxidative phosphorylation occurs in red blood cells T/F
In some cells glucose crosses the cell membrane by secondary active transport T/F
Bonus question (the answer can be worked out from material in chapter one) – the pH electrode has a semi-permeable membrane with the selective diffusion of hydrogen ions creating an electrical gradient which is measured. What equation is used to calculate the concentration of hydrogen ions from the electrical gradient?
And remember it’s the webinar today!
Devilsadvocate has made a list of LOs we haven’t addressed yet and I’ll post on some of these orphans this week. I’ve used Ganong for this one but it should be in most of the basic texts.
Glucose passively diffuses into the brain T/F
Circumventricular organs are within the blood brain barrier T/F
Ions cross the blood brain barrier readily T/F
Neurotransmitters cross the blood brain barrier readily T/F
The blood brain barrier can be disrupted by acute severe hypertension T/F
BT_RT 1.7 Describe blood groups and the physiological basis of transfusion reactions
I first heard of Bombay blood group this year. The H antigen is an intermediary in the production of A and B antigens, and is present in the red blood cells of those with O blood also. Bombay blood group has the recessive phenotype hh and does not express H antigens. It is very rare and will test falsely as O group unless specifically looked for. The antibody response to H antigens is predominantly IgM.
I don’t think this is examinable but I do think this is a useful concept to see how well you understand blood groups and transfusion reactions. You should be able to work out the answers given the above information.
A person with Bombay blood group is a universal donor TRUE/FALSE
A person with Bombay blood group can safely receive blood from an O- donor TRUE/FALSE
A person with Bombay blood group can safely receive blood from an AB- donor TRUE/FALSE
In the soap opera General Hospital Monica was group A, her husband Alan AB and her child tested O. Was Monica cheating on Alan?* YES/NO/MAYBE
Monica’s child was at risk of haemolytic disease of the newborn. TRUE/FALSE
*thanks to Wikipedia for this gem!
My hypothetical candidate was one of the 83.5% who passed the vivas at this exam. The vivas are in some ways easier than the SAQs as the examiners can prompt and rephrase questions to help you answer them, and in some ways more difficult as they test understanding. This candidate wasn’t able to compensate for their low SAQ mark, but should be very encouraged that they passed this component which requires both a breadth of knowledge and an ability to integrate the material.
This letter will have accompanying individual feedback sheets on questions/vivas that scored <40%, often with specific comments made by the marking examiner. It should be read in conjunction with the exam report too
This may be the first examination you have been unsuccessful in. This feedback, though difficult to read, can be a stepping stone to a successful attempt
More personal opinions and interpretations, this time on the SAQ feedback.
All the SAQs are now marked or scaled to out of 5 so in this section you are given your score for each question and your total score. In this section you need 40% to be invited to the vivas, that is a total of 30, or an average mark of 2 (borderline). I would also define a 2 as ‘the candidate has not demonstrated that they are performing at the level required in a specialty exam but rudimentary knowledge has been displayed and the examiner feels, based on that performance, that the candidate is worth inviting to the vivas to demonstrate their knowledge and understanding further’.
My hypothetical candidate will be invited to the vivas based on their SAQ score but they have a lot of ground to make up in the viva examination. This will be difficult but it is doable. Study is often more dynamic, interactive and effective leading up to the vivas.
I suggest you classify each SAQ based on
- whether it asks for factual material only, or integration
- whether it is clinically based
For example, question 7 in this exam asked to justify the dose of propofol used in different scenarios and requires integration of knowledge in a clinical setting, while question 8 in this exam just requires you to set down what you know about IV metoprolol.
Is there a pattern in your performance?
Question 15 scored 0 which suggests poor time management.
BT_PM 1.12 (Opioid receptors)
List the desired and adverse effects of opioids and the corresponding anatomical location of the receptors being activated
Opioids have multiple sites of action and many of their effects are undesirable. These should be considered in your patients, and other analgesic techniques used if harms potentially outweigh benefits.
Opioids can mediate analgesia through presynaptic primary sensory afferents T/F
Opioids can mediate analgesia in the dorsal horn of the spinal cord T/F
Opioids have no supra-spinal mediation of analgesia T/F
Immunosuppression is an adverse effect of opioids T/F
Biliary spasm is an adverse effect of opioids T/F
Bonus question, definitely not core material in answering this question but interesting. First paragraph of the pethidine entry on wikipedia leads you to the answer but it’s worth considering why the Germans were trying to develop drugs of this class in 1939.
Pethidine can cause mydriasis T/F