Draw and explain the characteristics of a quantal dose-response curve that describes the major clinical effects of rocuronium. Outline medications and medical conditions that shift the curve to the left or the right.
Neuromuscular blockers and opioids can be used as clinical examples to test candidates’ understanding of the various types of dose response curves. Why do we recommend 2 to 3 times the “ED95” as the intubating dose for muscle relaxants?
T / F a quantal dose-response curve is semi-logarithmic
T / F the y-axis shows % twitch height reduction, from 0 to 100%
T / F for the specific case of muscle relaxants, the ED50 refers to 50% of the population achieving a 95% reduction in twitch height, and is also referred to as the ED95, or ED50(95%)
T / F a right shift in the curve reflects reduced potency, and could be caused by a recent dose of neostigmine, or one week of bed rest
T / F hypothermia increases the potency of rocuronium
T / F patients with myasthenia gravis would have a left shifted curve
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