BT_GS 1.7 Explain the concept of pharmacokinetic modelling of single
and multiple compartment models and define:
· Half life
· Clearance
· Zero and first order kinetics
· Volume of distribution
· Bio-availability
· Area under the plasma concentration time curve
· Extraction ratio
TRUE/FALSE Initial volume of distribution of propofol is similar to plasma volume.
TRUE/FALSE A polyexponential curve can be expressed mathematically as
C = A/at + B/bt + C/ct
TRUE/FALSE Using a semi-log plot of plasma concentration vs time converts the curve to the sum of a number of straight lines
TRUE/FALSE Varea is calculated by extrapolating the second part of a semi-log plot back to the Y axis and using this concentration as an initial stirred volume.
TRUE/FALSE VDss is obtained by measuring plasma concentrations of drug during infusion to steady state
Primary LO of the Day 