Outline the genetic variations in the cytochrome P450 2D6 enzyme and discuss the clinical relevance for drugs used in the perioperative period.
This enzyme is responsible for much of the variation in efficacy and toxicity of some commonly used drugs.
This enzyme metabolises tramadol into a more active metabolite TRUE/FALSE
Ondansetron may be ineffective with poor metabolisers TRUE/FALSE
Patients from the middle east are more likely to be ultrarapid metabolisers TRUE/FALSE
Approximately 90% of caucasians are poor metabolisers TRUE/FALSE
This enzyme metabolises codeine into a more active metabolite TRUE/FALSE