This has been a popular topic in vivas (and the occasional SAQ) for ages. It’s an important and relevant topic that is not always well-covered in the basic texts.
BT_PM 1.18 Describe the pharmacology of opioids deposited in the epidural space or cerebrospinal fluid
With regard to epidural fentanyl (1 mcg.kg-1)
plasma concentrations of fentanyl are similar to the same dose given intramuscularly TRUE/FALSE
the duration of analgesia is 1 hour TRUE/FALSE
the CSF concentrations of fentanyl are maximal at 50 minutes TRUE/FALSE
the incidence of pruritis is greater than following an equi-analgesic dose of epidural morphine TRUE/FALSE
the onset of analgesia is around 2-5 minutes because fentanyl is highly lipid soluble TRUE/FALSE