SS_OB 1.9 Drug Variability in Pregnancy

SS_OB 1.9 Describe the influence of pregnancy on the pharmacokinetics and pharmacodynamics of drugs commonly used in anaesthesia and analgesia

TRUE/FALSE In pregnancy the average gain of 8 litres of total body water significantly increases the volume of distribution of hydrophilic drugs.

TRUE/FALSE Foetal and placental tissues provide another compartment for drug distribution.

TRUE/FALSE Pseudocholinesterase activity is decreased in pregnancy causing prolongation of succinylcholine block.

TRUE/FALSE Pregnancy reduces MAC by 25-30%.

TRUE/FALSE Nociceptive response thresholds are elevated in pregnancy.

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