Clearly a favourite of mine (see yesterday’s post and also this one)
BT_GS 1.3 Define and explain dose-effect relationships of drugs with reference to:
· Graded and quantal response
· Therapeutic index
· Potency and efficacy
· Competitive and non-competitive antagonists
· Partial agonists, mixed agonist-antagonists and inverse agonists
· Additive and synergistic effects of drug combinations
BT_GS 1.4 Describe efficacy and potency with reference to dose- response curves
Use the curve below as a basis for your graphs
1.Add axes to indicate that the curve is a graded dose-response curve for a full agonist. Show the ED50.
2.Draw on the same axes, the same agonist in the presence of a competitive antagonist. Indicate the important features on your curve.
3.Show a partial agonist (E=0.8) which is equipotent to the full agonist drawn
4.Show on the graph with the full agonist, a more potent partial agonist capable of producing 50% maximal effect
5.Are any of the curves 2-4 compatible with a graph representing the full agonist in the presence of a non competitive (irreversible) antagonist? If so, which one?
I’ll post the answers later in the week