BT_GS 1.3 Dose- effect relationships

I wanted to get you thinking about dose-effect curves as they are popular ( and sometimes pesky) little things in the vivas.

Tomorrow I will set some graphs for you to draw.

For today……

BT_GS 1.3 Define and explain dose-effect relationships of drugs with reference to:· Graded and quantal response

· Therapeutic index

· Potency and efficacy

· Competitive and non-competitive antagonists

· Partial agonists, mixed agonist-antagonists and inverse agonists

· Additive and synergistic effects of drug combinations

A quantal dose-response curves has axes of dose and proportion of population responding ( or % responding) T/F

The sigmoid shape of a quantal dose-response curve is because it is an example of a cumulative frequency distribution T/F

Quantal dose response curves show a graded response in a population T/F

Drug potency can be assessed using quantal dose-response curves T/F

Muscle relaxant dosing, using 2xED95 is determined from the ED50 on a quantal dose-response curve, where the quantal response is 95% twitch height reduction T/F

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