BT_GS 1.36 Muscle relaxant pharmacokinetics

BT_GS 1.36 Describe the pharmacokinetics of neuromuscular blocking agents

TRUE/FALSE The short duration of action of succinylcholine is due to its rapid hydrolysis by acetylcholinesterase at the neuromuscular junction

TRUE/FALSE The volume of distribution of muscle relaxants imply that they are essentially confined to the intravascular space

TRUE/FALSE Antiepileptic inducers of CP450 increase the rate of elimination of vecuronium but not mivacurium

TRUE/FALSE About 30% of an administered dose of cisatracurium is metabolised by ester hydrolysis

TRUE/FALSE All muscle relaxants bind to alpha 1 acid glycoprotein

2 thoughts on “BT_GS 1.36 Muscle relaxant pharmacokinetics

  1. Good evening, I was unable to find a good source that referred to all muscle relaxants and their property as an acid or a base.

    Established that roc/vec are bases and thus would bind to alpha 1 acid glycoproteins but unable to find the others (especailly curious about sux)

    Could you enlighten us with a source or your knowledge?

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  2. Try Evers & Maze Chapter 38.

    All is a brave word. In the exam we only ask about suxamethonium, the steroidal muscle relaxants and the benzylisoquinolones, but there are many others. Some examples include decamethonium, alcuronium, gallamine and fazadinum. Wikipedia lists some other ones I have never even heard of.

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