BT_PM 1.9 Analgaesic Agents

This is a huge LO. For the most part you are probably better off covering it when you do the individual agents. If you choose this approach, don’t forget methoxyflurane, anticonvulsants and antidepressants.

BT_PM 1.9 Describe the pharmacology of the following agents applicable to pain management, including: Opioids Tramadol Local anaesthetic agents (also refer to the Regional and local anaesthesia clinical fundamental) NSAIDs Paracetamol NMDA antagonists Anticonvulsants Antidepressants Corticosteroids Inhalational analgesics – nitrous oxide, methoxyflurane


TRUE/FALSE Paracetamol and Ketamine both exert analgesic effects via NMDA receptors

TRUE/FALSE Paracetamol has poor bioavailability

TRUE/FALSE Hepatotoxicity is an uncommon, immune mediated complication of paracetamol use

TRUE/FALSE Subanaesthetic doses of ketamine achieve analgesia via a specific competitive NMDA blockade

TRUE/FALSE Naloxone is minimally effective in reversing the effects of tramadol

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